GCTA (Yang et al., 2011) was used to assess SNP-based heritability (h2SNP). Analyses were conducted within group (ALSPAC, AFR, AMR, and EUR), using unrelated individuals and markers with MAF≥0.01. To assess genetic correlations between SRE and other relevant traits assessed in independent samples, summary statistics were uploaded to LD Hub (Zheng et al., 2017). We tested whether SRE was genetically correlated with traits in selected categories: anthropometric, brain volume, cognitive, education, hormone, metabolites, personality, psychiatric, reproductive, and smoking behavior.
