The advances produced by the TREC I centers influenced the culture of their academic institutions more broadly. Interview participants reported that senior leaders and investigators at their institutions showed growing interest in TD team science as their TREC I centers produced exciting science, brought in additional funding related to TREC I activities, and communicated these achievements to their colleagues. This transformation in colleagues’ receptivity toward TD team science was particularly evident at academic institutions that were homes to NCI-designated cancer centers, where there was a natural affinity for the research conducted at the TREC I centers.