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Chunk #29 — Discussion

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Fine mapping of calcineurin (PPP3CA) gene reveals novel alternative splicing patterns, association of 5'UTR trinucleotide repeat with addiction vulnerability, and differential isoform expression in Alzheimer's disease.
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to be expressed at less than 1% of the levels of expression of these major isoforms. CNEX1-10 and 3-12 isoforms are expressed in brain only, where they are likely to participate in regulation of brain-specific calcineurin isoform activity. However, isoforms that are expressed at low levels in whole tissue samples might be selectively expressed in small cell subpopulations where they might play more substantial roles.