Details on the Collaborative Study on the Genetics of Alcoholism (COGA) data collection and procedures have been published previously [37, 38]. Briefly, since 1990 over 17,000 individuals from families densely affected with AUD and from community comparison families have participated in the COGA study. Participants were administered a comprehensive evaluation that included clinical assessments of substance use and psychiatric disorders using the Semi-Structured Assessment for the Genetics of Alcoholism (SSAGA) [39] research interview. In a subset of families, DNA was collected, and a brain functioning protocol was administered that included measures of EEG during resting state, such as measures of neural connectivity. The current COGA protocol began in 2019 when the project turned to a one-time follow-up assessment (SSAGA interviews, questionnaires, and a brain functioning battery) of previous COGA participants currently in two life stages: participants aged 50 or older (born 1973 or earlier), the majority of whom have a lifetime history of AUD, and participants aged 30–40 (born 1982–1993) from a longitudinal study of youth and young adult offspring from COGA families, approximately half of whom have a lifetime
