A.K., R.T., T.O., N.-B.W., and D.H. conceived the study and designed the experiments. O.P. and J.S. provided samples for the study. M.N., K.N., and M.O. established and provided Sendai virus vector for reprogramming experiments. C.V., C.A., K.K.P., and D.H. performed epigenetic analyses. R.M. and N.-B.W. performed differentiation and functional analyses. B.V.H., J.K., and J.W. helped in the bioinformatics analyses. A.K. and R.T. performed all other experiments and analyzed the data. A.J., T.O., N.-B.W., and D.H. provided funding for the work. All authors contributed to writing of the manuscript.