MHP and SOC were responsible for study concept, design, and execution. MHP, JB, and LW performed statistical analyses. MHP, LW, JB, and SOC drafted the manuscript. AK oversaw day‐to‐day lab operations and provided review of the manuscript for important intellectual content. BS and VR provided insight into analytical strategy. UZ contributed to theoretical design and reviewed the manuscript. MS contributed to the subjective response interpretation. HJE, TF, and JN contributed to the genetic analysis and reviewed the manuscript for important intellectual content. GP, CK, and BP determined FHD in the COGA dataset. All authors critically reviewed content and approved the final version for publication.