An aggregate genetic risk score (AGRS) was then calculated for each participant. The AGRS included genotypes of candidate polymorphisms that were identified as important candidates in bupropion response in at least two smoking cessation trials (ie, SLC6A3 VNTR, DRD4 exon 3 VNTR, COMT Val158Met polymorphism and DRD2 TaqIA as outlined above).
