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Chunk #34 — Conclusion

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A critical review of the first 10 years of candidate gene-by-environment interaction research in psychiatry.
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indirect replications (36, 37) and the low false positive rate among direct replications (36), well-powered studies conducted with the express purpose of closely replicating previous findings should be viewed as more scientifically important than novel “groundbreaking” cG×E results or indirect replications. The practice of according the most prestige to novel findings contributes to the ambiguous state of cG×E research and potentially to the proliferation of type I errors.