Chunk #70 — SIMULATION STUDY

Source

Disease model distortion in association studies.

Embedded

yes

Text

Due to the complex LD structure in the human genome, and also ascertainment effects from GWAS study designs, it is difficult to evaluate the impact of distortion on GWAS results analytically. For this reason, we also adopted a simulation approach, using existing data and methods to simulate realistic GWAS samples under various disease models.