Figure 1 displays the three sets of GWAS results used to make comparisons. Figure 1A displays the univariate GWAS, focusing on a single phenotype (ALCP-total). Figure 1B displays the multivariate GWAS, with the seven indicators used to estimate the model. From these two models, we derive three sets of GWAS summary statistics: the univariate GWAS results for ALCP-total (path 1) [18, 19], the common factor GWAS results for EXT (path 2) [17], and the problematic alcohol use specific GWAS (path 3; ALCP-specific). These results allow us to dissect genetic variance in problematic alcohol use by comparing the results of ALCP-total to both EXT and ALCP-specific.
