This study provides recent, national age trends in the prevalence of SUDs across adulthood by gender and race/ethnicity. Results show higher rates of SUDs for men compared to women for most substances, and that a racial/ethnic crossover occurs, with rates higher for Black compared to White participants at later ages. Findings suggest the importance of early prevention and treatments for all subgroups, but that Black adults at older ages may also be at increased risk. In addition, this paper showed the utility of TVEM for examining nuanced periods of disparities in substance use by age and subgroup.