These findings should be considered within the context of certain limitations. First and most importantly is that this study only included individuals of European ancestry, due to the majority European ancestral composition of the discovery GWAS from which the PRS were derived from, as cross-ancestry predictions are at risk for producing highly biased estimates. A future direction of this work is to create PRS derived from the Million Veteran Program GWAS of AUD, which includes considerable numbers of individuals of African and Hispanic/Latino ancestries, despite the sex-imbalance noted above. While this is the largest study of EEG coherence in adolescence and young adults conducted to date, larger sample sizes are still needed to confirm both trajectories of EEG coherence and associations with alcohol use behavior and PRS. In addition, it will be important for future work to pair EEG studies with fMRI to combine the advantages of the superior spatial resolution of MRI and the superior temporal resolution of EEG, to better understand findings from both modes of measuring functional connectivity. Finally, future studies will directly compare PRS for AUD with PRS for alcohol consumption to further disentangle the effects of genetic risk for AUD on brain function.
