The main finding is that participants with higher impulsivity reported stronger stimulant and weaker sedative effects during IV ethanol infusion. Notably, higher impulsivity was associated with a steeper increase in stimulant effects during the first half of clamped ethanol infusion (between the +10 and +30 timepoints). In contrast, lower impulsivity was associated with a steeper increase in sedative response in the first half of clamped ethanol infusion. These findings were most pronounced following the high dose targeting a BrAC of 100mg%. These results were found regardless of family history and gender effects. The findings shifted following the end of clamped ethanol infusion, such that differences by impulsivity level dissipated and were no longer as clear. It is not surprising that we observed changes in subjective response after the end of ethanol infusion, given that BALs were no longer uniform and had begun to decline. Impulsivity did not influence physiologic responses to alcohol.
