SNPs3D candidate lists can be generated on demand, with little delay, and so have the advantage of taking into account all the current literature. On the other hand, there is a great deal of relevant specialized knowledge in the scientific community that is either not in the literature, or very difficult to extract in a useful way. The Genetic Association Database (GAD) is an archive of human genetic association studies of complex diseases and disorders [47] that provides an alternative approach to compiling the relevant information. Any user may submit information about an association between a disease and a gene, creating a mechanism of capturing community knowledge. We expect that in the long run, the most effective candidate lists will be complied by a hybrid of the two approaches.
