to their methylation levels prior to treatment (Perroud et al., 2013). Further, single nucleotide polymorphisms (SNPs) have been shown to mediate the relationship between child abuse and adult outcomes. Demethylation of FKBP5 in carriers of the FKBP5 rs1360780 risk allele was found to mediate the relationship between childhood abuse and increased PTSD prevalence in adulthood (Klengel et al., 2013). These data lend support to the idea that maltreatment during childhood has vast implications for the epigenome which likely contribute to behavioral and disease states associated with maltreatment.
