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Chunk #31 — GM Changes in Alzheimer's Disease — Strengths and Limitations of Voxel-based Mapping Methods

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Mapping gray matter development: implications for typical development and vulnerability to psychopathology.
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anatomical template. As in VBM, statistics can be compiled and group differences in growth rates, or effects of medication, risk genes, or covariates of interest, can be plotted at each location the brain. In recent longitudinal MRI studies, TBM has provided among the best results in terms of longitudinal precision (smallest sample size needed to detect a 25% slowing of pathological changes). Even so, a wide variety of morphometric methods are being applied to developmental brain data. Each is sensitive to very different aspects of brain structure; some provide numeric summaries and others provide 3D maps or movies.