Risk-related decision-making appears to predict susceptibility for substance use disorders in humans and addiction-related behaviors in animals, but the progression of drug experience appears to alter these relationships, producing task specific changes in impulsive decision-making. While less is known about the underlying mechanistic basis of risky decision-making, from the neural circuitry and pharmacological perspectives, it is evident that this domain at least partially shares a neural circuitry and neuropharmacology with inhibitory response control and delay discounting (Figure 1; Table 2). A great deal more work needs to be conducted to compare test of risky decision-making to one another and to the other dimensions of impulsivity discussed in sections 2 and 3.
