Chunk #19 — Materials and Methods — INDIVIDUALS — — Meta-analysis

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Novel loci for major depression identified by genome-wide association study of Sequenced Treatment Alternatives to Relieve Depression and meta-analysis of three studies.

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QC procedures for GenRED and GAIN-MDD (similar to methods described above for controls) are described in Supplementary Methods. For GAIN-MDD, we excluded slightly more ancestry outliers based on principal component scores. Genomic control λ values are shown in Table 3 for each analysis. QQ plots are shown in Tables S8–11.