A central tenet of the Human Brain Connectome project, which aims to accurately map the structural connectivity of the human brain, is that this structural architecture allows for rich functional network dynamics to unfold and these, in turn, enable an extensive repertoire of behaviours (Sporns, 2013; Sporns et al., 2005). Whereas many studies have begun to define the relationship between structural and functional connectivity (Honey et al., 2009; Evans, 2013), the link to cognition, especially on a network level, is still relatively unexplored. In the current study we address this major gap by examining how focal structural damage affects functional connectivity and how these disruptions map onto the specific cognitive deficit.
