We completed several sensitivity analyses. First, we completed a sensitivity analysis in Caucasian subjects, as they were our largest racial demographic with sufficent numbers in all genotype groups. Similar effects were obtained; there was a significant 2-way interaction for time × DAT1 genotype (F7, 613 = 2.76, p = 0.011) and a significant 3-way interaction for time × DAT1 gentype × OPRM1 genotype (F7, 613 = 2.69, p = 0.010) on SHAS scores. Second, we added BAC as a covariate and examined effects in all subjects and then in Caucasians only. Adding BAC, did not alter the findings. Specifically, when BAC was added to the model in all subjects, there was a significant 2-way interaction for time × DAT1 genotype (F7, 801 = 2.14, p = 0.037) and a significant 3-way interaction for time × DAT1 gentype × OPRM1 genotype (F7, 801 = 2.28, p = 0.027) on SHAS scores. In Caucasians only, there was a significant 2-way interaction for time × DAT1 genotype (F7, 591 = 2.65, p = 0.011) and a significant 3-way interaction for time × DAT1 gentype × OPRM1 genotype (F7, 613 = F7, 591 = 2.67, p = 0.010) on SHAS scores.
