All subjects included in these meta-analyses were current or former smokers of European ancestry. Results from 34 datasets, which include a total of 38,617 unrelated subjects who were assessed for cigarettes-per-day, contributed to the meta-analyses. Eight of the datasets were drawn from family-based studies and contributed only a subset of unrelated individuals to these analyses. Table 1 gives sample sizes and demographics of each participating study sample. Text S7.describes additional details for each dataset, including ascertainment criteria and genotyping methods, and documents that four datasets are also members of other consortia. All datasets contributed to the analyses of smoking. A subset of these 34 datasets also had information on lung cancer cases and lung-cancer-free smoker controls (6 datasets, N = 13,614 smokers) and/or COPD cases and COPD-free smoker controls (4 datasets, N = 6,182 smokers). The data for these traits are described in Table 2 and Table 3 respectively.
