Polygenicity may be a general feature of complex biomedical diseases. 128,129 Common variant SNP effects have been estimated to explain large proportions of the phenotypic heritability for a wide range of diseases: BIP and SCZ; 69,130 T1DM, T2DM, Crohn’s disease, rheumatoid arthritis, celiac disease, and coronary artery disease; 70,77 and continuous traits (height, intelligence, and body mass). 70,131,132 These results are consistent with suggestions that the “missing heritability” 133 is merely hidden. 132
