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Chunk #69 — 4. Discussion — 4.1. Reduced left lateral parietal but preserved mid-frontal old/new effects in schizophrenia

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Current source density (CSD) old/new effects during recognition memory for words and faces in schizophrenia and in healthy adults.
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As a final remarkable observation, the randomization tests of task-related differences in early and late old/new effects indicated for healthy adults a differential activation of left frontolateral regions (i.e., early inverted old/new effects) and left parietal regions (late old/new effects), each indicating greater activation when recognizing words than faces. It is intriguing that the CSD-PCA approach, in combination with unbiased randomization tests, implicated an involvement of regions that are entirely consistent with the classical language-related areas associated with speech production (Broca’s area) and speech comprehension (including Wernicke’s area; cf. Price, 2000).