No genes met the criteria for genome-wide significance (p<2.8*10−6), but the most associated gene was Dual specificity tyrosine-phosphorylation-regulated kinase 1A (DYRK1A) gene (located at 21q22.13). Within the DYRK1A gene, 30 SNPs had a p-value below p<10−5 and there were an additional 96 SNPs that reached nominal significance (p<.05) in the gene, yielding converging evidence of association (see Figure S1). To see whether we could find independent evidence for involvement of this gene, we checked the associations in both study cohorts separately. The DYRK1A SNPs in the first study cohort yielded similar p-values as compared to the combined study design. In the second study cohort, no SNPs were significant at p<0.05.
