structural variation should also be explored. Epigenetic factors almost certainly also play a role in a disorder such as PTSD10,73, which has traumatic stress as its precursor. Many other functional genomics tools can and should be brought to bear on the study of PTSD, expanding the scope of inquiry to encompass a holistic, integrative functional genomic analysis74 of this common, serious, and yet still poorly understood and inadequately treated neuropsychiatric disorder.