Given that beta EEG is highly heritable and is related to several externalizing behaviors and SUDs, genetic analysis of beta EEG may aid in our understanding of underlying brain function in individuals at risk for a range of externalizing disorders. The primary aim of this study was to conduct a GWAS of fast beta EEG power (bipolar occipital derivation, chosen due to high heritability observed in previous studies33) in families of AA from the Collaborative Study on the Genetics of Alcoholism (COGA), a recently ascertained family sample densely affected with AD and co-occurring externalizing disorders (for example, SUD, ADHD). The secondary aims of this study were to examine the functional and behavioral significance of GWAS findings.
