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Chunk #30 — Results — Between-group differences in efficient connectivity in data set 1 — Correlation between the mean EC strength and addiction severity in data set 1

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Atypical effective connectivity from the frontal cortex to striatum in alcohol use disorder.
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Negative correlations (FDR correction, P = 0.05) were observed between addiction severity (AUDIT and MAST scores) and the mean EC strength from the left pre-SMA to right putamen (AUDIT: r = −0.504, P = 0.005, FDR corrected, P = 0.008; MAST: r = −0.554, P = 0.001, FDR corrected, P = 0.004), from the right dACC to right putamen (AUDIT: r = −0.491, P = 0.006, FDR corrected, P = 0.008; MAST: r = −0.551, P = 0.002, FDR corrected, P = 0.005). The results indicated significant positive correlations between addiction severity (AUDIT and MAST scores) and the mean EC strength from the right NACC to left pre-SMA (AUDIT: r = −0.566, P = 0.001, FDR corrected, P = 0.004; MAST: r = 0.523, P = 0.003, FDR corrected, P = 0.006). Detailed information is shown in Table 4. The correlation between the mean EC strength and addiction severity (AUDIT and MAST scores) was still evident after controlling for patient’s the FTND scores. Detailed information is shown in Table 5.Table 4Correlation between EC strength and severity of alcohol dependence in