Polygenic score analyses indicated that individuals with AUD had an increased average polygenic risk for AUD than healthy controls (p = 0.00003; Fig. 2). Polygenic scores were linked to alternative mRNA splicing in the CEA (p = 0.035), trending in the NAc and PFC (all p < 0.099) and non-significant in the BLA (p = 0.119; Fig. 2; see Supplementary Files S2–S3). Given limitations of sample size and sparse genomic coverage, we encourage the reader to take caution in interpreting results from our polygenic score analyses.
