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Chunk #52 — Results — Deconstruction of mRNA networks by loss of nFGFR1 signaling

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Cerebral organoids reveal early cortical maldevelopment in schizophrenia-computational anatomy and genomics, role of FGFR1.
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We then analyzed network formation by 861 NCC genes, which were affected by FGFR1(SP-/NLS)(TK-) (Fig. 6). Significantly, the networks formed by the top 200 positively and 200 negatively correlated genes in control β-galactosidase transfected NCCs were deconstructed in the NCCs transfected with FGFR1(SP-/NLS)(TK-) (Fig. 7). Genes forming these nFGFR1-dependent positive and negative correlative networks represented several of the neuro-ontogenic categories (Fig. 6).