abuse, rs9829896-C, specifically in AAs. The trans-eQTL pattern between the protective rs9829896-C allele and reduced CREBBP gene expression is consistent with prior indications related to drug-seeking behavior. Mice with CREBBP depleted in the nucleus accumbens show impaired sensitivity and reward from cocaine exposure, suggesting that behavioral response to cocaine is regulated, at least in part, by CREBBP.(Malvaez et al., 2011) Assuming that the same pattern holds in humans, we expect that attenuation in drug rewarding effects due to reduced CREBBP expression would decrease susceptibility to abusing drugs. Altogether, these gene expression patterns for KAT2B and CREBBP suggest a common pathway leading to downstream effects on CREB and the broader cAMP pathway.
