The mechanisms by which alcohol causes cell injury are still not clear. A major pathway that is a focus of considerable research is the role of lipid peroxidation and oxidative stress in alcohol toxicity [1–4]. Many pathways have been suggested to play a key role in how alcohol induces oxidative stress including redox state changes, mitochondrial damage, ethanol-induced increase in endotoxin levels and TNFα production, mobilization of iron, ethanol modulation of antioxidant defense systems, and ethanol induction of CYP2E1[1–4].
