a Bonferroni correction for 22,121 genes in 49 tissues. We present our TWAS results based on per gene P values combined across all available tissues, resulting in a 5 (phenotype) × 22,121 (gene) matrix of P values. Pathway enrichment was also conducted using a weighted regression approach58 with the TWAS per-tissue P values to quantify the enrichment of identified genes in each pathway.
