Based on earlier studies our a priori hypothesis was that we would find phenotypic associations within the distal region of CRHBP. Nevertheless, in the African Americans the five distal SNPs were not in LD and therefore we could not predict which of these SNPs might have an effect. Therefore we applied a False Discovery Rate (FDR) correction (Benjamini et al., 2001) for comparisons across the five SNPs. In contrast, based on earlier publications our hypothesis was that there would be no main or G × E effects on suicidality of the two proximal SNPs, rs3792738 and rs6453267 and therefore we applied FDR corrections for all 7 CRHBP SNPs. The analysis of additive effects of FKBP5 and CRHBP variation was strongly hypothesis-driven and no corrections were warranted. For CRHR1, one haplotype block extended distally across the gene and included seven SNPs. There were two proximal SNPs that were not in LD and were therefore independent of each other and of the haplotype block. Therefore an adequate Bonferroni correction for these 2 SNPs would be 0.05/3 = 0.017.
