Trajectories of brain development across the two-year follow-up interval were compared between adolescents who remained alcohol free from baseline to Time 2 and those who began to use alcohol during the follow-up interval. Whole-brain cortical thickness, white matter extent, fractional anisotrophy and mean diffusivity were examined. For these analyses, age at initial enrollment, sex, scanner status (upgrade or not at Time 2), and the time interval between assessments were entered as nuisance covariates.
