The following groups of lean (Fa/?) and obese (fa/fa) Zucker rats were studied: lean untreated controls (Lean), obese untreated controls (Obese), and obese treated with tesaglitazar 3 μmol/kg/day (Tesaglitazar) for 3 weeks. This dose gives a close to maximal plasma glucose, insulin and triglyceride lowering in ob/ob mice [16]. Tesaglitazar was dosed daily at 13:00 for 3 wk by oral gavage. Untreated control rats were also gavaged according to the same schedule with an equal volume of vehicle (0.5% carboxymethyl cellulose, 2.5 mL/kg).
