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Chunk #37 — Discussion

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Brain expression quantitative trait locus and network analyses reveal downstream effects and putative drivers for brain-related diseases.
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We used brain-specific co-regulation networks to study several brain-related GWAS studies and prioritized genes that show significantly enriched co-regulation with genes inside GWAS loci. For ALS, this revealed a limited but significant set of genes located outside of currently known ALS loci, which might lead to a better understanding of the poorly understood pathways that cause ALS.