Schizophrenia and bipolar disorder are serious mental illnesses (SMI) that affect more than 2% of adults1,2. There has been much recent progress in understanding the genetic basis for schizophrenia3–8. Yet understanding the molecular mechanisms linking risk loci to disease phenotypes, and characterizing disease pathways remains an open challenge. Here we have compiled a large-scale functional genomics resource in order to understand the interplay between genetic regulation, gene expression, chromatin accessibility and disease in the human brain. We have generated RNA-seq (n = 991) and ATAC-seq (n = 269) profiles from the dorsolateral prefrontal cortex specimens and SNP genotypes (n = 1076) from 4 separate brain banks. The genotype data includes 98 samples without RNA- or ATAC-seq data released with the anticipation of including functional data for these in a future release.
