in transgenic mice2021244647 and by a higher number of D1/D2 heteromer in the rat and monkey Acb2526. The shell compartment of the Acb was significantly more enriched in D1/D2 MSNs than the core compartment, supporting the notion that the latter is more similar to the dorsal striatum than the former, which has been described as a transition zone between the striatum and the extended amydgdala48. The fact that the D1/D2 MSNs form the vast majority of MSNs in the medial area of the shell compartment, as noted here, is interesting since this medial region of the Acb shell is known to be involved in feeding behaviors49505152 as well as in the response to noxious stimuli52. Whether or not the D1/D2 MSNs present in the Acb play a role in the antidepressant and anxiolytic effects observed after disruption of the D1-D2 complex53 remains to be investigated.
