p=0.02), suggesting that the nRE does not participate in propagation of theta oscillations between HC and PFC. In contrast, PFC-HC coherence of 2–5 Hz oscillation significantly decreased after lidocaine by 0.39 ± 0.04 (Fig. 6C) from 0.73 ± 0.03 control to 0.34 ± 0.04 after lidocaine (Fig. 6D; p< 0.001, n=32). The effect was similar in dHC and vHC (Fig. 6B). These results support the hypothesis that PFC-to-HC delta synchrony is at least partly mediated by the nRE, as pharmacologic inactivation of this nucleus significantly decreases coherence between these two brain regions.
