were previously unexplored. Thus, we used Indiana alcohol-preferring (P) rats, which are a well-validated preclinical model of familial risk for excessive drinking (i.e., “family-history positive”), and a comparison strain with no family history, Wistar rats. We hypothesized that the intention to drink or abstain would be encoded in populations of neurons in the PFC. Furthermore, since individuals with a positive family history display greater PFC responses to alcohol associated stimuli (Tapert et al., 2003; Kareken et al., 2010), we also hypothesized that P rats would display a more robust intention signal compared to Wistar.
