applied examples presented here. Thus, this approach to addressing collider bias may not extend to outcome variables with other distributions. An extension of our simulation pipeline to accommodate logistic regression for binary outcomes performed poorly. The addition of PCs increased the variance of the PRS estimate slightly and the distribution of corrected PRS effect sizes was not reliably centered on the true value. The complete results of these simulations are available on the GitHub page associated with this work (https://github.com/thomasns0/PCA_Collider.git).
