of the same schizophrenia and control iPSC lines revealed impaired migration in 2D cultures31, polarity32, decreased neurite numbers33, reduced synaptic maturation33–36, and decreased activity in the schizophrenia neurons35,36. These changes forecasted a potential disruption of early brain development in schizophrenia. Therefore, in the present study we followed the neuro-ontogenic potency of these characterized iPSC lines, from the stem cell/progenitor stage through the formation of cortical layers using the 3D cerebral organoid model.
