The imaging study was designed to achieve the target of 100,000 subjects, each scanned once, over 5-6 years at three dedicated, identical centers operating 7 days/week, each scanning 18 subjects/day7. This places tight timing constraints, corresponding to one subject imaged every 36 minutes (see Online Methods). The first imaging center was built to establish feasibility and scanned 10,000 subjects over a two-year ramp-up period. Two further identical centers are being commissioned, with the three centers strategically positioned at population hubs: Manchester, Reading and Newcastle.
