GENOA cohorts were combined via inverse variance-weighted meta-analysis of variants with MAF > 0.01 and Rsq > 0.8 using METAL71 with genomic control enabled. For characterization of FURIN, an additional inverse variance-weighted meta-analysis of chromosome 15 was conducted including all studies with no overlapping samples (GENOA + MVP without SAGE and Yale-Penn + Partners; Cases N = 16,849, Controls N = 379,493, Total N = 396,342, Effective Total N = 52,508).
