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Chunk #36 — Materials and Methods — Modeling strategies for imputation datasets

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A flexible and accurate genotype imputation method for the next generation of genome-wide association studies.
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However, a more salient question is whether there is any useful information to be gained from jointly modeling untyped SNPs, and whether this information can be obtained with a reasonable amount of computational effort. Most imputation methods, including our new algorithm, implicitly assume that such information is not worth pursuing, whereas BEAGLE assumes that it is. We explore this question further in the sections that follow.