There is also preliminary evidence for the possibility of genetic influences on response to psychosocial interventions, including those incorporating RP strategies. In a secondary analysis of the Project MATCH data, researchers evaluated posttreatment drinking outcomes in relation to a GABRA2 variant previously implicated in the risk for alcohol dependence [102]. Analyses included MATCH participants of European descent who provided a genetic sample (n = 812). Those carrying the high-risk GABRA2 allele showed a significantly increased likelihood of relapse following treatment, including a twofold increase in the likelihood of heavy drinking. Furthermore, GABRA2 interacted with treatment condition to influence drinking outcomes. Among those with the high-risk genotype, drinking behavior did not appear to be modified by treatment, with outcomes being similar regardless of treatment condition. However, treatment differences emerged in the low-risk genotype group, such that TSF produced the best outcomes, followed by MET [102]. In another psychosocial treatment study, researchers in Poland examined genetic moderators of relapse following inpatient alcohol treatment [103]. Results showed that polymorphisms in BDNF (Val66Met) and COMT (Val158Met) significantly predicted relapse probability. Overall, evidence for genetic
