As described previously22, the amygdala reactivity paradigm used in the Discovery cohort (DNS) consists of 4 blocks of a face-processing task interleaved with 5 blocks of a sensorimotor control task. During task blocks, participants view a trio of faces (with neutral, angry, fearful or surprised expressions) and match 1 of 2 faces (bottom) identical to a target face (top). During control blocks, participants match simple geometric shapes. In the Replication cohort (TAOS), the task consisted only of Angry and Fearful Faces. Thus, for consistency between samples, we focused our analyses on the Anger + Fear > Shapes contrast in our Discovery cohort. Performance was monitored and participants with accuracy < 75% were excluded from analysis.
