All the variants in Table 5, except three, are located within the annotated genes listed. We found the linkage disequilibrium, D’ and r2, between each of the three variants that were close to, but not within, the annotated gene and a second variant within the annotated gene using data from HapMap (release 27) (www.hapmap.org). Between variant rs10492065 downstream of KCNA1 and rs4766311 in KCNA1 (26,423 nucleotides apart), D’ = 0.97 and r2 = 0.027 in the Caucasian (CEPH) population, and between rs3825786 downstream of PLA2G4F and rs2280248 in PLA2G4F (2,660 nucleotides apart), D’ = 1 and r2 = 0.149 in the Yoruba population. The linkage disequilibrium was low between rs2180 upstream of the OLIGO2 gene and rs6517137 in OLIGO2 (56,500 nucleotides apart) (D’ = 0.14, r2 = 0.001) in the CEPH population). However, this variant may itself be functional.
