within both of these nuclei since application of competitive, selective CRF1 or CRF2 receptor antagonists resulted in an enhancement or depression of glutamatergic EPCS. A similar tonic endogenous action of CRF ligands was not observed under control conditions in the medial prefrontal cortex (Orozco-Cabal et al. 2006). This latter result further emphasizes that CRF effects are different depending upon the CNS synapse being investigated. Most of these studies in the Gallagher group aimed to investigate the action of CRF on glutamatergic synapses in relation to cocaine administration. There is very poor data on EtOH–CRF–glutamate interaction.
