Chunk #18 — Materials and methods — Mendelian randomization analyses

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Meta-analysis of up to 622,409 individuals identifies 40 novel smoking behaviour associated genetic loci.

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× 10−11)rs29474112:614168G/ATMEM18IntergenicSI0.830.0189 (0.004)4.97 × 10−10 (0.00017/7.1 × 10−8)Previously associated with BMIrs5283012:45154908A/GSIX3IntergenicSI0.380.0136 (0.002)4.12 × 10−11 (1.77 × 10−6/3.8 × 10−7)rs67388332:104150891T/CTMEM182#IntergenicSI0.33−0.018 (0.003)8.66 × 10−14 (1.63 × 10−6/4.4 × 10−11)r2 = 0.69 between rs6738833 and rs12616219 (Table 1) in European samples of the 1000 Genomes Projectrs130264712:137564022T/CTHSD7BIntronicSI0.180.0127 (0.003)2.45 × 10−8 (0.00028/3.0 x 10−5)rs67249282:156005991C/TKCNJ3IntergenicSI0.32−0.011 (0.003)4.47 × 10−8 (0.0019/4.8 × 10−5)rs130224382:162800372G/ASLC4A10IntronicSI0.270.0146 (0.003)1.41 × 10−11 (0.0005/8.1 × 10−8)rs18692443:5724531A/GLOC105376939IntergenicSI0.320.0123 (0.003)2.76 × 10−9 (0.00040/4.1 x 10−6)rs354387123:85588205T/CCADM2IntronicSI0.250.017 (0.003)1.99 × 10−13 (1.15 × 10−5/3.2 × 10−10)rs68833515:22193967T/CCDH12IntronicSI0.340.0129 (0.003)4.69 × 10−8 (0.0010/1.4 × 10−6)rs64149465:87729711C/ATMEM161BIntronicSI0.32−0.0137 (0.003)5.27 × 10−10 (3.63 × 10−5/2.8 × 10−7)rs117477725:166992708C/TTENM2IntronicSI0.250.0144 (0.003)6.20 × 10−9 (0.011/2.2 × 10−7)rs93209956:98726381G/APOU3F2IntergenicSI0.180.0150 (0.003)1.70 × 10−8 (0.00079/6.1 × 10−7)rs102555167:1675621G/AELFN1IntergenicSI0.33−0.0139 (0.003)2.86 × 10−10 (0.0021/1.8 × 10−7)rs108078397:3344629G/ASDK1IntronicSI0.190.0162 (0.003)8.93 × 10−11 (0.0026/4.4 × 10−8)rs69657407:117514840T/GCTTNBP2IntergenicSI0.31−0.0126 (0.003)9.66 × 10−9 (5.56 × 10−6/2.8 × 10−6)rs117762938:27418429T/CEPHX2IntronicSI0.12−0.0200 (0.003)2.23 × 10−12 (0.00011/8.9 × 10−9)rs11776293 is an eQTL for CHRNA2 in cerebellum in GTExrs15626128:59817068G/ATOXIntronicSI0.35−0.0112 (0.003)1.15 × 10−9 (1.42 × 10−5/2.9 × 10−5)rs38579148:93184065C/TRUNX1T1IntergenicSI0.190.0157 (0.003)1.54 × 10−9 (0.065/7.1 × 10−8)rs27998499:86752641C/TRMI1IntergenicSI0.22−0.0156 (0.003)1.94 × 10−8 (0.026/4.8 × 10−8)rs648219010:22037809A/GLOC107984214IntronicSI0.170.0146 (0.003)8.85 × 10−9 (0.0021/9.5 × 10−7)rs452368911:7950797G/AOR10A6IntergenicSI0.27−0.012 (0.003)7.77 × 10−9 (0.00030/2.2 × 10−5)rs93300613:38350193A/GTRPC4IntronicSI0.32−0.0143 (0.003)3.50 × 10−8 (0.022/9.6 × 10−8)rs55789915:47643795A/CSEMA6DIntronicSI0.260.0157 (0.003)2.99 × 10−13 (4.46 × 10−5/1.0 × 10−8)rs7660858219:4474725A/CHDGFRP2IntronicSI0.029−0.0360 (0.007)8.50 × 10−9 (0.012/4.3 × 10−8)Chromosome (Chr) and position (Pos) for each SNV is given for hg19 build